Diflucan medicine contains the active ingredient fluconazole, which belongs to the antifungal medicines used for various medical purposes.
Diflucan as a single dose treatment in the dose of 150 capsule is indicated for vaginal thrush in women and in men who are suffering from thrush on the penis. Fluconazole is used for the treatment of Esophageal Candidiasis Oropharyngeal Candidiasis Cryptococcal Meningitis Prophylaxis of Candidiasis with BMT and other conditions caused by susceptible Candida species of fungi.
Flucanazole is highly selective in inhibition of fungal cytochrome P-450-dependent enzyme lanosterol 14-alpha-demethylase. This property of the medicine is responsible for the fungistatic activity of fluconazole.
Dosage forms
Dosage form is chosen with accordance to different factors such as age, condition being treated, severity of the condition. Diflucan is available in the following dosage forms: injected solution in 2mg/mL; oral suspension in 10mg/mL, 40mg/mL; 50,100, 150 and 200 mg tablets.
Uses and dosing
Diflucan in the form of tablets is used in the dosage of 200 mg and then 100 mg for the treatment of oropharyngeal candidiasis. The therapy is usually adjusted for as long as 2 weeks or even longer.
The treatment of esophageal candidiasis involves usage of Diflucan in the 200 mg tablets, then 100 mg afterwards. The doses up to 400 mg per day are possible if a patient tolerates the medicine well. The time of treatment usually lasts for 3 weeks.
Vaginal candidiasis treatment of uncomplicated character demands taking only one pill of Diflucan in the dose of 150 mg. In complicated cases this dose 150 mg is to be taken three times during 72 hours. And then once in a month during a period adjusted by your doctor.
Patients with cryptococcal meningitis usually receive 400 mg of fluconazole in the first day of the treatment and then 200 mg each day during the period of 10-12 weeks until the results of the tests of cerebrospinal fluid are culture negative.
Candida species of fungi cause infections accompanied by inflammation and discharge, soreness and redness of the skin, rash and others.
Fluconazole kills the Candida fungi by interfering with their cell membranes. It prevents fungi from producing ergosterol, an essential component of fungal cell membranes.
Fluconazole effectively treats the infections if it is used correctly and during the recommended period of time.
Contraindications of Fluconazole
• Known hypersensitivity to the main component and other ingredients in the medicine;
• Pregnancy;
• Severe renal impairment and other severe health problems;
• Conditions that increase QT-prolongation risk
Use during pregnancy
Single dose of 150 mg for vaginal candidiasis is possible in pregnant women. Still the alternative treatments should be considered due to existing risks of miscarriage in pregnant women.
Lactating women belong to the category which is also at risk because Fluconazole enters the breast milk and can be potentially harmful for a nursing baby.
Diflucan side effects
Common side effects noticed after the medicine is taken can be any of the following: abdominal pain, nausea, vomiting, diarrhea, and headache, rash. Infrequent are the side effects causing gastrointestinal symptoms like decrease in appetite or taste disturbance.
For more information you should contact your doctor. It is important to get a proper professional consultation before you start the treatment.
Diflucan with other medicines
The combination of Diflucan with certain other medicines can be unsafe or cause unpleasant side effects. Check with your doctor the list of drugs which can interact with fluconazole or read the label available with the medicine. Try to avoid taking your medicines together with Diflucan. Take your medicines separately if it is possible.